5-(tert-Butyl)-2-chloropyridine

Specification: Enterprise standard
CAS: 102236-19-1

 

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Basic Information

Product Name: 5-(tert-Butyl)-2-chloropyridine

Chinese Name: 5-(叔丁基)-2-氯吡啶

Molecular Formula: C₉H₁₂ClN

Molecular Weight: 169.65 g/mol

Structure: This compound is a pyridine ring substituted with a chlorine atom at the 2-position and a bulky tert-butyl group at the 5-position.


5-(tert-Butyl)-2-chloropyridine is a halogenated heterocyclic compound used as an intermediate in organic synthesis. The chlorine atom provides a reactive site for substitution or cross-coupling reactions, while the tert-butyl group influences steric and electronic properties, useful for pharmaceutical and agrochemical applications.

 

Main Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals.

Building block for heterocyclic compounds with tailored steric properties.

Precursor in metal-catalyzed cross-coupling reactions.

 

Typical Applications

Participates in Suzuki, Stille, and Buchwald-Hartwig cross-coupling reactions.

Used for nucleophilic aromatic substitution to introduce various functional groups.

 

Applied in the design of heteroaromatic molecules for drug discovery and materials science.