Product Name: 2-Chloro-4-iodopyridine
Chinese Name: 2-氯-4-碘吡啶
Molecular Formula: C₅H₃ClIN
Molecular Weight: 239.44 g/mol
Structure: A pyridine ring substituted with a chlorine atom at the 2-position and an iodine atom at the 4-position, representing a dihalogenated heteroaromatic compound useful for selective functionalization.
2-Chloro-4-iodopyridine is an important intermediate in organic synthesis, particularly valuable for selective cross-coupling reactions due to the differing reactivity of the chlorine and iodine substituents. This allows for stepwise introduction of various functional groups on the pyridine scaffold, widely applied in pharmaceutical and material chemistry.
Pharmaceutical Intermediate
Used for the synthesis of pyridine-containing bioactive molecules and drug candidates.
Selective Cross-Coupling Reactions
Facilitates Suzuki, Sonogashira, and Stille couplings with selective activation of the iodine substituent, while the chlorine can be used in subsequent modifications.
Material Science
Applied in synthesizing heteroaromatic compounds for use in organic electronics and catalysis.
Selective Suzuki Coupling
Enables selective coupling at the iodine site, preserving the chlorine for further functionalization.
Sonogashira Coupling
Supports coupling with terminal alkynes to build conjugated molecular frameworks.
Sequential Functionalization
The differential reactivity of halogens allows stepwise modification strategies in complex molecule synthesis.
